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KMID : 0387820230300010011
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Clinical Pediatric Hematology-Oncology
2023 Volume.30 No. 1 p.11 ~ p.20
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Acute Complications of Pediatric Allogeneic Hematopoietic Stem Cell Transplantation and Their Effects on Survival: A Single-Center Experience in Korea
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Lee Kyoung-Min
Ahn Won-Ki
Han Jung-Woo
Lyu Chuhl-Joo
Hahn Seung-Min
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Abstract
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Background: Acute complications within 100 days after allogeneic hematopoietic stem cell transplantation (HSCT) can increase immediate mortality as well as the risk of chronic complications and morbidity. A comprehensive review collecting systemic complications following transplantation would be important in pediatric patients.
Methods: We report a retrospective study of pediatric patients who underwent alloge-neic HSCT during the 11 years (2009-2020), and their acute complications after transplantation within 100 days. A total 227 pediatric patients’ (90 females, 137 males) data were collected.
Results: Among the patients, 62.6% (N=142) suffered from acute graft-versus-host dis-ease, and 118 (52.0%) patients had an acute infection. Pulmonary complications oc-curred in 52 (22.9%) patients followed by hepatic sinusoidal obstruction syndrome in 30 (18.1%) patients. In the study, 19 died within the first 100 days after HSCT (8.4%), and the 5-year overall survival rate of the patients was 65.4%.
Conclusion: This study widens the understanding of acute toxicities of pediatric HSCT. A significant number of children still have experienced a variety of acute in-fectious or non-infectious complications after allogeneic HSCT that contribute to morbidity and mortality. Therefore, continuous efforts are needed to reduce them.
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KEYWORD
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Hematopoietic stem cell transplantation, Pediatric, Graft versus host dis-ease, Infection
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